Journal article

A biomarker panel for peripheral arterial disease

Eric T Fung, Andrew M Wilson, Fujun Zhang, Nathan Harris, Kim A Edwards, Jeffrey W Olin, John P Cooke

VASCULAR MEDICINE | SAGE PUBLICATIONS LTD | Published : 2008

Abstract

Peripheral arterial disease (PAD) is common, but often not diagnosed. A biomarker index would be useful to raise suspicion of PAD, so as to trigger appropriate vascular testing and management. The study comprised 540 individuals: 197 individuals with both coronary artery disease and peripheral arterial disease (CAD + PAD); 81 with CAD only; and 262 with no hemodynamically significant disease (NHSD) of the coronary or peripheral arteries. Multiple linear regression was performed to generate a biomarker panel score that could predict ankle-brachial index (ABI). Logistic regression was used to investigate the relationship between disease status and the panel score as well as other risk factors ..

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Grants

Awarded by National Heart, Lung and Blood Institute


Awarded by NIH


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

This study was supported in part by grants from the National Heart, Lung and Blood Institute (R01 HL63685, RO1 HL-75774 and T32 HL07708; JPC), and NIH grant M01 RR 00070 (General Clinical Research Center, Stanford University School of Medicine). Dr Cooke had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.