Journal article

Characterization of the innate immune signalling pathways in hepatocyte cell lines

S Preiss, A Thompson, X Chen, S Rodgers, V Markovska, P Desmond, K Visvanathan, K Li, S Locarnini, P Revill

JOURNAL OF VIRAL HEPATITIS | WILEY-BLACKWELL | Published : 2008

Abstract

Hepatitis B virus (HBV) infection is a major cause of liver-related morbidity and mortality. Toll-like receptors (TLRs) have recently been recognized to play an important role in the pathogenesis of chronic hepatitis B (CH-B). Furthermore, manipulation of TLR signalling pathways shows potential as an antiviral therapeutic strategy. Whether hepatocytes themselves possess intact TLR signalling pathways remains controversial. It is critical that cell culture models be developed to allow investigation of the interaction between HBV and the TLR signalling pathways. We have screened three hepatocyte cell lines for the integrity of pro-inflammatory responses and antiviral cytokines following stimul..

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Grants

Awarded by NIH


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

PR is supported by NIH grant no. AIO60449. SP is supported by the Bristol-Myers Squibb freedom to discover fund. AT is supported by NHMRC postgraduate scholarship. KL is supported by NIH grant no. AI069285. The authors thank Ashley Mansell for helpful comments during the course of the project.