CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population

BN Wray; J Stankovich; L Whittock; T Dwyer; AL Ponsonby; IAF van der Mei; B Taylor; J Dickinson; S Foote; BJ McMorran

Journal article

CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population

BN Wray, J Stankovich, L Whittock, T Dwyer, AL Ponsonby, IAF van der Mei, B Taylor, J Dickinson, S Foote, BJ McMorran

Journal of Neuroimmunology | ELSEVIER | Published : 2008

DOI: 10.1016/j.jneuroim.2008.02.001

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P < 0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype. © 2008 Elsevier B.V. All rights reserved.