Book Chapter

The Use of High Density Genotyping in Animal Health

ME Goddard

Developments in Biologicals | KARGER | Published : 2008

Abstract

The sequencing of genomes, such as that of the cow, has led to the discovery of thousands of single nucleotide polymorphisms (SNPs). By combining this knowledge with new methods that can genotype thousands of SNPs efficiently, it has become possible to carry out genome-wide association studies in domestic animals to map genes for complex traits, including disease resistance, using the linkage disequilibrium between the SNPs and the unknown genes affecting the trait of interest. Although experiments using 10,000 SNPs and 384 animals have found many significant associations, power calculations suggest that we need >50,000 SNPs and >1000 animals to map genes explaining most of the genetic varia..

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University of Melbourne Researchers