Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice
Michael K Bird, Jeppe Kirchhoff, Elvan Djouma, Andrew J Lawrence
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | CAMBRIDGE UNIV PRESS | Published : 2008
The metabotropic glutamate receptor 5 (mGlu5) has been implicated in ethanol- and drug-seeking behaviours in rodent studies. Here we examine a number of ethanol-related behavioural assays in mice lacking mGlu5 and wild-type littermates. In a two-bottle free-choice paradigm, mGlu5-deficient mice consumed less ethanol with a reduced preference compared to wild-type mice. Indeed, mGlu5-deficienct mice were ethanol-avoiding at both concentrations of ethanol proffered (5% and 10% v/v). However, there was no difference in the rate of hepatic ethanol and acetaldehyde metabolism between genotypes and consumption of saccharin was similar. In a conditioned place preference study, mGlu5-deficient mice ..View full abstract
This study was supported by the NHMRC (Australia), of which A.J.L. is a Senior Research Fellow.