Journal article

A Differential Role for the Adenosine A(2A) Receptor in Opiate Reinforcement vs Opiate-Seeking Behavior

Robyn Mary Brown, Jennifer Lynn Short, Michael Scott Cowen, Catherine Ledent, Andrew John Lawrence



The adenosine A(2A) receptor is specifically enriched in the medium spiny neurons that make up the 'indirect' output pathway from the ventral striatum, a structure known to have a crucial, integrative role in processes such as reward, motivation, and drug-seeking behavior. In the present study we investigated the impact of adenosine A(2A) receptor deletion on behavioral responses to morphine in a number of reward-related paradigms. The acute, rewarding effects of morphine were evaluated using the conditioned place preference paradigm. Operant self-administration of morphine on both fixed and progressive ratio schedules as well as cue-induced drug-seeking was assessed. In addition, the acute ..

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