Journal article

A Differential Role for the Adenosine A(2A) Receptor in Opiate Reinforcement vs Opiate-Seeking Behavior

Robyn Mary Brown, Jennifer Lynn Short, Michael Scott Cowen, Catherine Ledent, Andrew John Lawrence

NEUROPSYCHOPHARMACOLOGY | NATURE PUBLISHING GROUP | Published : 2009

Abstract

The adenosine A(2A) receptor is specifically enriched in the medium spiny neurons that make up the 'indirect' output pathway from the ventral striatum, a structure known to have a crucial, integrative role in processes such as reward, motivation, and drug-seeking behavior. In the present study we investigated the impact of adenosine A(2A) receptor deletion on behavioral responses to morphine in a number of reward-related paradigms. The acute, rewarding effects of morphine were evaluated using the conditioned place preference paradigm. Operant self-administration of morphine on both fixed and progressive ratio schedules as well as cue-induced drug-seeking was assessed. In addition, the acute ..

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