A differential role for the adenosine A2A receptor in opiate reinforcement vs opiate-seeking behavior

RM Brown; JL Short; MS Cowen; C Ledent; AJ Lawrence

Journal article

A differential role for the adenosine A2A receptor in opiate reinforcement vs opiate-seeking behavior

RM Brown, JL Short, MS Cowen, C Ledent, AJ Lawrence

Neuropsychopharmacology | NATURE PUBLISHING GROUP | Published : 2009

DOI: 10.1038/npp.2008.72

Abstract

The adenosine A2A receptor is specifically enriched in the medium spiny neurons that make up the 'indirect' output pathway from the ventral striatum, a structure known to have a crucial, integrative role in processes such as reward, motivation, and drug-seeking behavior. In the present study we investigated the impact of adenosine A2A receptor deletion on behavioral responses to morphine in a number of reward-related paradigms. The acute, rewarding effects of morphine were evaluated using the conditioned place preference paradigm. Operant self-administration of morphine on both fixed and progressive ratio schedules as well as cue-induced drug-seeking was assessed. In addition, the acute loco..

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University of Melbourne Researchers

Robyn M Brown Author

Andrew Lawrence Author

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Grants

Funding Acknowledgements

This work was supported by a program grant (236805) from the National Health and Medical Research Council of Australia of which AJL is a senior research fellow. An equipment grant from ANZ Trustees (William Buckland Foundation) contributed toward the purchase of mouse operant chambers.