Journal article

Adiposity gain during childhood, ACE I/D polymorphisms and metabolic outcomes

Anne-Louise Ponsorby, Leigh Blizzard, Angela Pezic, Jenny A Cochrane, Justine A Ellis, Ruth Morley, Jo L Dickinson, Michele M Sale, Stephen M Richards, Terence Dwyer

OBESITY | WILEY | Published : 2008


We aimed to (i) determine the relative importance of childhood gain in upper body adiposity for insulin resistance (IR) and triglyceridemia (TG); (ii) examine whether the associations between adiposity and metabolic indices were more evident in those with the ACE DD genotype. We examined a birth cohort study of 292 children with measures in the neonatal period (day 4) including subscapular and triceps skinfolds; repeat skinfold measures at age 8, cardiorespiratory (CR) fitness, IR by the homeostasis model assessment (HOMA) equation (HOMA-IR) and serum triglyceride (TG) concentrations and measures of ACE I/D gene variants. A multiple linear regression analysis incorporating a life course appr..

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Awarded by US National Institutes of Health


Funding Acknowledgements

We thank the research nurses who conducted the at-birth measurements, Carole Goff and Philippa Boon who undertook the tracing of the cohort and conducted field measurements, Michael Martin who assisted with tracing and fieldwork in 1996/1997. J.A.C. for long-term cohort data management including supervision of tracing and follow-up, the schools that provided facilities. and especially the children and the families of children who participated in the study. This study was funded by the National Health and Medical Research Council of Australia. The Tasmanian Infant Health Survey was funded by the National Health and Medical Research Council of Australia, US National Institutes of Health (grant 001 HD28979-01A1), Tasmanian State Government, Australian Rotary Health Research Fund, Sudden Infant Death Syndrome Research Foundation, National Sudden Infant Death Syndrome Council of Australia, Community Organizations' support program of the Department of Human Services and Health, Zonta International, Wyeth Pharmaceuticals, and Tasmanian Sanatoria After-Care Association. A.-L.P. was supported by a National Health and Medical Research Council PHRCD Fellowship. R.M. was supported by VicHealth (The Victorian Health Promotion Foundation). M.M.S. was supported by a Career Development Award from the American Diabetes Association.