Secondary metabolism: regulation and role in fungal biology
Ellen M Fox, Barbara J Howlett
CURRENT OPINION IN MICROBIOLOGY | CURRENT BIOLOGY LTD | Published : 2008
Filamentous fungi produce a diverse array of secondary metabolites--small molecules that are not necessary for normal growth or development. Secondary metabolites have a tremendous impact on society; some are exploited for their antibiotic and pharmaceutical activities, others are involved in disease interactions with plants or animals. The availability of fungal genome sequences has led to an enhanced effort at identifying biosynthetic genes for these molecules. Genes that regulate production of secondary metabolites have been identified and a link between secondary metabolism, light and sexual/asexual reproduction established. However, the role of secondary metabolites in the fungi that pr..View full abstract
We thank the Grains Research and Development Corporation, Australia, for funds that support our research.