Journal article

Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders

Tsutomu Takahashi, Alison R Yung, Murat Yuecel, Stephen J Wood, Lisa J Phillips, Ian H Harding, Bridget Soulsby, Patrick D McGorry, Michio Suzuki, Dennis Velakoulis, Christos Pantelis

SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2008

Abstract

An increased prevalence of large cavum septum pellucidum (CSP), a marker of midline neurodevelopmental abnormality, has been reported in schizophrenia. However, not all studies have been able to replicate this finding and very few studies have been conducted in large samples. In the current study, magnetic resonance imaging was used to assess the presence of an abnormal CSP in 162 patients with first-episode psychosis (FEP), 89 patients with chronic schizophrenia, 135 ultra high-risk (UHR) individuals, and 87 controls. The prevalence of a large CSP (>5.6 mm) did not differ between the groups (9.3% of the FEP patients, 11.2% of the chronic schizophrenia patients, 11.1% of the UHR individuals,..

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