Journal article

Vestibular, saccadic and fixation abnormalities in genetically confirmed Friedreich ataxia

Michael C Fahey, Phillip D Cremer, Sweet Aw, Lynette Millist, Michael J Todd, Owen B White, Michael Halmagyi, Louise A Corben, Veronica Collins, Andrew J Churchyard, Kim Tan, Lionel Kowal, Martin B Delatycki

BRAIN | OXFORD UNIV PRESS | Published : 2008

Abstract

Friedreich ataxia (FRDA), the commonest of the inherited ataxias, is a multisystem neurodegenerative condition that affects ocular motor function. We assessed eye movement abnormalities in 20 individuals with genetically confirmed FRDA and compared these results to clinical measures. All subjects were assessed with infrared oculography. Fifteen individuals underwent a full protocol of eye movement recordings. Ten subjects were analysed using two-dimensional scleral coil equipment and five using three-dimensional scleral coil recording equipment. We also recorded visual quality of life, Sloan low contrast letter acuity and Friedreich Ataxia Rating Scale scores to compare to the visual measure..

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