Journal article
Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes
Anne-Marie Sims, Neil Shephard, Kim Carter, Tracy Doan, Alison Dowling, Emma L Duncan, John Eisman, Graeme Jones, Geoffrey Nicholson, Richard Prince, Ego Seeman, Gethin Thomas, John A Wass, Matthew A Brown
JOURNAL OF BONE AND MINERAL RESEARCH | WILEY-BLACKWELL | Published : 2008
DOI: 10.1359/JBMR.071113
Abstract
UNLABELLED: Using a moderate-sized cohort selected with extreme BMD (n = 344; absolute value BMD, 1.5-4.0), significant association of several members of the Wnt signaling pathway with bone densitometry measures was shown. This confirms that extreme truncate selection is a powerful design for quantitative trait association studies of bone phenotypes. INTRODUCTION: Although the high heritability of BMD variation has long been established, few genes have been conclusively shown to affect the variation of BMD in the general population. Extreme truncate selection has been proposed as a more powerful alternative to unselected cohort designs in quantitative trait association studies. We sought to ..
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