Journal article

Application of Epidemiology to Change Health Policy: Defining Age-Related Thresholds of Bone Mineral Density for Primary Prevention of Fracture

Margaret J Henry, Julie A Pasco, Kerrie M Sanders, Mark A Kotowicz, Geoffrey C Nicholson

JOURNAL OF CLINICAL DENSITOMETRY | ELSEVIER SCIENCE INC | Published : 2008

Abstract

In Australia, benefits for antifracture therapies have been available for patients with osteoporosis and a prior fracture. No benefits were available to those with no prior fracture. We aimed to define, in women with no prior fracture, age-related thresholds of bone mineral density (BMD) associated with fracture risk equivalent to that of women with prior fracture and osteoporosis. A case-control study of women (> or =50 yr) was conducted, including 291 fracture cases and 823 controls. BMD was measured at the proximal femur and posterior anterior (PA) spine. A fracture risk score (FRS) for the group with no prior fracture was calculated with discriminant analysis. The thresholds for equivale..

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