Bisphosphonate Treatment in Chronic Recurrent Multifocal Osteomyelitis

Abstract

Objective: To test the safety and efficacy of biphosphonates in chronic recurrent multifocal osteomyelitis (CRMO). Study design: Five patients with CRMO, all of whom had ongoing pain and loss of function despite conventional treatment with non-steroidal anti-inflammatory agents, were treated with pamidronate (1 mg/kg/dose with a dosing frequency of 2 to 4 monthly for a total treatment duration of 12 to 42 months). Results: Pain decreased after the first infusion for 4 of 5 patients, with symptomatic improvement maintained with time. Significant improvement was seen in radiological lesions for these 4 patients. Conclusion: Bisphosphonates appear to be a useful and safe adjunctive treatment in..