Journal article

Bisphosphonate treatment in chronic recurrent multifocal osteomyelitis

Peter J Simm, Roger C Allen, Margaret R Zacharin

JOURNAL OF PEDIATRICS | MOSBY-ELSEVIER | Published : 2008

Abstract

OBJECTIVE: To test the safety and efficacy of biphosphonates in chronic recurrent multifocal osteomyelitis (CRMO). STUDY DESIGN: Five patients with CRMO, all of whom had ongoing pain and loss of function despite conventional treatment with non-steroidal anti-inflammatory agents, were treated with pamidronate (1 mg/kg/dose with a dosing frequency of 2 to 4 monthly for a total treatment duration of 12 to 42 months). RESULTS: Pain decreased after the first infusion for 4 of 5 patients, with symptomatic improvement maintained with time. Significant improvement was seen in radiological lesions for these 4 patients. CONCLUSION: Bisphosphonates appear to be a useful and safe adjunctive treatment in..

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