Journal article

Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom

J Mcveron, ME Ramsay, AR Mclean

EPIDEMIOLOGY AND INFECTION | CAMBRIDGE UNIV PRESS | Published : 2008

Abstract

A rise in invasive Haemophilus influenzae type b (Hib) infections occurred 8 years after vaccine introduction in the United Kingdom. Aspects of Hib vaccine delivery unique to the United Kingdom have been implicated. The authors developed a fully age-structured deterministic susceptible-infected-resistant-susceptible mathematical model, expressed as a set of partial differential equations, to better understand the causes of declining vaccine effectiveness. We also investigated the consequences of the vaccine's impact on reducing Hib transmission for maintenance of immunity. Our findings emphasized the importance of maintaining high post-immunization antibody titres among age groups at greates..

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University of Melbourne Researchers