Journal article

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPAR alpha and UCP2 expression in rats

Anna G Holmes, Jose L Mesa, Bronwyn A Neill, Jason Chung, Andrew L Carey, Gregory R Steinberg, Bruce E Kemp, Robert J Southgate, Graeme I Lancaster, Clinton R Bruce, Matthew J Watt, Mark A Febbraio



Chronic elevations in interleukin (IL)-6 have been associated with insulin resistance, but acute IL-6 administration can enhance insulin sensitivity. Our aim was to exogenously administer IL-6 to rats to elicit either chronic or repeated acute elevations in systemic IL-6. We hypothesized that a continuous elevation of IL-6 would inhibit glucose tolerance and insulin sensitivity while acute intermittent elevations would improve it. Male Wistar rats were treated for 14d with recombinant human IL-6 (2.4 microy) or saline administered either by miniosmotic pump (continuous IL-6) or via twice-daily injection (intermittent IL-6). Glucose and insulin tolerance tests were performed following 14-d tr..

View full abstract


Awarded by National Health and Medical Research Council of Australia, NHMRC

Funding Acknowledgements

This work was supported by a grant from the National Health and Medical Research Council of Australia (NHMRC 342115). A G H was and B A N is supported by an Australian Post graduate award. A L C and C R B are supported by Peter Doherty Post Doctoral Fellowships (NHMRC). B E K is an Australian Research Council (ARC) Federation Fellow. R J S is an ARC APD Fellow. M J W is an RD Wright Fellow (NHMRC), and M A F is a Principal Research Fellow (NHMRC). J L M was a visiting student from The University of Grenada, Spain.