Journal article

Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages

Tai Du, Gulay Filiz, Aphrodite Caragounis, Peter J Crouch, Anthony R White

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS | Published : 2008

Abstract

Copper has an important role in cancer growth, angiogenesis, and metastasis. Previous studies have shown that cell-permeable metal ligands, including clioquinol (CQ) and pyrrolidine dithiocarbamate, inhibit cancer cell growth in cell culture and in vivo. The mechanism of action has not been fully determined but may involve metal-mediated inhibition of cancer cell proteasome activity. However, these studies do not fully account for the ability of cell-permeable metal ligands to inhibit cancer cell growth without affecting normal cells. In this study, we examined the effect of CQ on macrophage-mediated inhibition of HeLa cancer cell growth in vitro. When CQ was added to RAW 264.7 macrophage-He..

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University of Melbourne Researchers