Journal article

The extracellular matrix protein WARP is a novel component of a distinct subset of basement membranes

Justin M Allen, Bent Brachvogel, Peter G Farlie, Jamie Fitzgerald, John F Bateman

MATRIX BIOLOGY | ELSEVIER SCIENCE BV | Published : 2008

Abstract

WARP is a recently described member of the von Willebrand factor A domain superfamily of extracellular matrix proteins, and is encoded by the Vwa1 gene. We have previously shown that WARP is a multimeric component of the chondrocyte pericellular matrix in articular cartilage and intervertebral disc, where it interacts with the basement membrane heparan sulfate proteoglycan perlecan. However, the tissue-specific expression of WARP in non-cartilaginous tissues and its localization in the extracellular matrix of other perlecan-containing tissues have not been analyzed in detail. To visualize WARP-expressing cells, we generated a reporter gene knock-in mouse by targeted replacement of the Vwa1 g..

View full abstract