Journal article

POTENTIAL ROLE OF NITRIC OXIDE IN CONTRACTION-STIMULATED GLUCOSE UPTAKE AND MITOCHONDRIAL BIOGENESIS IN SKELETAL MUSCLE

Glenn K McConell, Glenn D Wadley

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | WILEY | Published : 2008

Abstract

1. The present review discusses the potential role of nitric oxide (NO) in the: (i) regulation of skeletal muscle glucose uptake during exercise; and (ii) activation of mitochondrial biogenesis after exercise. 2. We have shown in humans that local infusion of an NO synthase inhibitor during exercise attenuates increases in skeletal muscle glucose uptake without affecting blood flow. Recent studies from our laboratory in rodents support these findings in humans, although rodent studies from other laboratories have yielded conflicting results. 3. There is clear evidence that NO increases mitochondrial biogenesis in non-contracting cells and that NO influences basal skeletal muscle mitochondria..

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University of Melbourne Researchers

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Funding Acknowledgements

The authors acknowledge their collaborators on the studies mentioned, especially Dr Scott Bradley, Associate Professor Bronwyn Kingwell, Associate Professor Stephen Rattigan, Troy Merry and Kelly Linden. The authors extend their appreciation to the participants involved in their research and thank the National Health and Medical Research Council of Australia and Diabetes Australia for funding.