Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment
GK McConell, A Manimmanakorn, RS Lee-Young, BE Kemp, KC Linden, GD Wadley
JOURNAL OF APPLIED PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2008
Short-term exercise training in humans attenuates AMP-activated protein kinase (AMPK) activation during subsequent exercise conducted at the same absolute workload. Short-term 5-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR) administration in rats mimics exercise training on skeletal muscle in terms of increasing insulin sensitivity, mitochondrial enzymes, and GLUT4 content, but it is not known whether these adaptations are accompanied by reduced AMPK activation during subsequent exercise. We compared the effect of 10 days of treadmill training (60 min/day) with 10 days of AICAR administration (0.5 mg/g body weight ip) on subsequent AMPK activation during 45 min of treadmill exercise i..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by grants from the National Health and Medical Research Council of Australia (Project grant number 237002) and Diabetes Australia.