2-Day versus 5-day famciclovir as treatment of recurrences of genital herpes: Results of the FaST study

Abstract

DosageDuration:Single dose of 500 mg, then 250 mg bid (= 500 mg daily) for 2 days; 125 mg bid (= 250 mg daily) for 5 days.Patients:873 outpatients. 2-day Famvir course: n=433, of whom 315 had relapse (180 males and 135 females, mean age 40 years; 289 Caucasian) and 289 entered second randomization (137 on 2-day and 152 on 5-day). 5-day Famvir course: n=440, of whom 301 had relapse (165 males and 136 females, mean age 40 years; 273 Caucasian) and 277 entered second randomization (148 on 2-day and 129 on 5-day).Results:Overall, 253 (29%) patients did not experience a relapse during the study. The proportion of relapses with lesions present 5.5 days after initiating Famvir treatment was less in..