Journal article

C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment

Anne K Voss, Joanne M Britto, Mathew P Dixon, Bilal N Sheikh, Caitlin Collin, Seong-Seng Tan, Tim Thomas

DEVELOPMENT | COMPANY OF BIOLOGISTS LTD | Published : 2008

Abstract

Neuronal migration is integral to the development of the cerebral cortex and higher brain function. Cortical neuron migration defects lead to mental disorders such as lissencephaly and epilepsy. Interaction of neurons with their extracellular environment regulates cortical neuron migration through cell surface receptors. However, it is unclear how the signals from extracellular matrix proteins are transduced intracellularly. We report here that mouse embryos lacking the Ras family guanine nucleotide exchange factor, C3G (Rapgef1, Grf2), exhibit a cortical neuron migration defect resulting in a failure to split the preplate into marginal zone and subplate and a failure to form a cortical plat..

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University of Melbourne Researchers