Non-Chromosomal, Non-Iatrogenic Premature Ovarian Failure in an Adolescent Population: A Case Series

Abstract

Study Objective: To review a cohort of patients with non-chromosomal, non-iatrogenic premature ovarian failure (POF) presenting to the Gynaecology Clinic of the Royal Children's Hospital, Melbourne. Design: Case series. Setting: The Department of Gynaecology, Royal Children's Hospital, Melbourne, Victoria, Australia. Participants: Adolescent patients with non-chromosomal, non-iatrogenic premature ovarian failure. Results: Seventeen patients with non-chromosomal, non-iatrogenic POF were identified between 1990 and 2006. The average age at the time of diagnosis was 16.1 years. 58.8% (10/17) presented with primary amenorrhea, 23.5% (4/17) with secondary amenorrhea and 17.6% (3/17) with oligomen..