Journal article

Mice expressing ACE only in the heart show that increased cardiac angiotensin II is not associated with cardiac hypertrophy

Hong D Xiao, Sebastien Fuchs, Ellen A Bernstein, Ping Li, Duncan J Campbell, Kenneth E Bernstein

American Journal of Physiology - Heart and Circulatory Physiology | AMER PHYSIOLOGICAL SOC | Published : 2008


In the heart, angiotensin II has been suggested to regulate cardiac remodeling and promote cardiac hypertrophy. To examine this, we studied compound heterozygous mice, called angiotensin-converting enzyme (ACE) 1/8, in which one ACE allele is null, whereas the other ACE allele (the 8 allele) targets expression to the heart. In this model, cardiac ACE levels are about 15 times those of wild-type mice, and ACE expression is reduced or eliminated in other tissues. ACE 1/8 mice have 58% the cardiac ACE of a previous model, called ACE 8/8, but both ACE 1/8 and ACE 8/8 mice have ventricular angiotensin II levels about twofold those of wild-type controls. Despite equivalent levels of cardiac angiot..

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