Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver
Sherley Visinoni, Barbara C Fam, Amy Blair, Christian Rantzau, Benjamin J Lamont, Russell Bouwman, Matthew J Watt, Joseph Proietto, Jenny M Favaloro, Sofianos Andrikopoulos
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | AMER PHYSIOLOGICAL SOC | Published : 2008
Increased endogenous glucose production (EGP) predominantly from the liver is a characteristic feature of type 2 diabetes, which positively correlates with fasting hyperglycemia. Gluconeogenesis is the biochemical pathway shown to significantly contribute to increased EGP in diabetes. Fructose-1,6-bisphosphatase (FBPase) is a regulated enzyme in gluconeogenesis that is increased in animal models of obesity and insulin resistance. However, whether a specific increase in liver FBPase can result in increased EGP has not been shown. The objective of this study was to determine the role of upregulated liver FBPase in glucose homeostasis. To achieve this goal, we generated human liver FBPase trans..View full abstract
This work is supported by a Biomedical Postgraduate Scholarship from the National Health and Medical Research Council of Australia (S. Visinoni). S. Andrikopoulos was supported by a RD Wright Biomedical Career Development Award from the National Health and Medical Research Council of Australia. M. Watt is supported by a RD Wright and Monash fellowship.