Activation of cholecystokinin (CCK1) and serotonin (5-HT3) receptors increases the discharge of pancreatic vagal afferents
Bashair M Mussa, Daniela M Sartor, Anthony JM Verberne
EUROPEAN JOURNAL OF PHARMACOLOGY | ELSEVIER | Published : 2008
Cholecystokinin and serotonin are released from the gastrointestinal tract in response to the products of digestion and play critical roles in mediating pancreatic secretion via vago-vagal reflex pathways. This study was designed to investigate the effects of activation of cholecystokinin CCK(1) and serotonin (5-hydroxytryptamine, 5-HT) 5-HT(3) receptors on pancreatic vagal afferent discharge and to determine whether there is an interaction between these receptors. Male Sprague Dawley rats anaesthetised with isoflurane (1.5%/100% O(2)) were used in all experiments. The effects of systemic administration of cholecystokinin and the serotonin 5-HT(3) receptor agonist phenylbiguanide on pancreat..View full abstract
This work was supported by the Austin Hospital Medical Research Foundation.