Activation of cholecystokinin (CCK1) and serotonin (5-HT3) receptors increases the discharge of pancreatic vagal afferents

Abstract

Cholecystokinin and serotonin are released from the gastrointestinal tract in response to the products of digestion and play critical roles in mediating pancreatic secretion via vago-vagal reflex pathways. This study was designed to investigate the effects of activation of cholecystokinin CCK1 and serotonin (5-hydroxytryptamine, 5-HT) 5-HT3 receptors on pancreatic vagal afferent discharge and to determine whether there is an interaction between these receptors. Male Sprague Dawley rats anaesthetised with isoflurane (1.5%/100% O2) were used in all experiments. The effects of systemic administration of cholecystokinin and the serotonin 5-HT3 receptor agonist phenylbiguanide on pancreatic vagal..