Journal article

Relaxin family peptide receptors - from orphans to therapeutic targets

Emma T van der Westhuizen, Michelle L Halls, Chrishan S Samuel, Ross AD Bathgate, Elaine N Unemori, Steven W Sutton, Roger J Summers



The relaxin family peptides have distinct expression profiles and physiological functions. Several of them are the cognate ligands for 4 G-protein-coupled relaxin family peptide receptors (RXFPs; formerly LGR7, LGR8, GPCR135, GPCR142). The relaxin/RXFP1 system has roles in reproductive physiology but is also involved in fibrosis, wound healing and responses to infarction. Relaxin has a potential use in congestive heart failure where fibrosis plays an important role in organ failure. The INSL3/RXFP2 system has biological roles in reproductive biology that may have limited therapeutic potential. However, the recently characterized relaxin-3/RXFP3 system is important in stress/anxiety and body ..

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Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia and by the Australian Research Council. Emma T. van der Westhuizen is a NHMRC Dora Lush (Biomedical) Post Graduate Scholar and Michelle L. Halls is an Australian Postgraduate Scholar and recipient of a Monash University Faculty of Medicine, Nursing and Health Sciences Excellence Award. Ross A.D. Bathgate is a NHMRC Senior Research Fellow and Chrishan S. Samuel is a National Heart Foundation of Australia (NHFA)/NHMRC R.D. Wright Fellow. Steven W. Sutton is a Senior Scientist at Johnson & Johnson Pharmaceutical Research & Development, LLC, whose work was solely supported by that company.