Journal article

Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis

Qi Xu, Edna D Lekgabe, Xiao-Ming Gao, Ziqiu Ming, Geoffrey W Tregear, Anthony M Dart, Ross AD Bathgate, Chrishan S Samuel, Xiao-Jun Du



The effect of endogenous relaxin on the development of cardiac hypertrophy, dysfunction, and fibrosis remains completely unknown. We addressed this question by subjecting relaxin-1 deficient (Rln1-/-) and littermate control (Rln1+/+) mice of both genders to chronic transverse aortic constriction (TAC). The extent of left ventricular (LV) remodeling and dysfunction were studied by serial echocardiography over an 8-wk period and by micromanometry. The degree of hypertrophy was estimated by LV weight, cardiomyocyte size, and expression of relevant genes. Cardiac fibrosis was determined by hydroxyproline assay and quantitative histology. Expression of endogenous relaxin during the course of TAC ..

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