Vancomycin heteroresistance in bloodstream isolates of Staphylococcus capitis
Danae D'mello, Andrew J Daley, Muhammad Shihab Rahman, Yue Qu, Suzanne Garland, Christopher Pearce, Margaret A Deighton
JOURNAL OF CLINICAL MICROBIOLOGY | AMER SOC MICROBIOLOGY | Published : 2008
Nine Staphylococcus capitis isolates from blood cultures of newborns were examined for resistance to vancomycin. MICs were within the susceptible range, but population profiling revealed a resistant subpopulation. Only isolates with the largest subpopulation were identified as heteroresistant to vancomycin by Etest. This finding may have therapeutic implications.
This work was supported by internal funding from the School of Applied Sciences, RMIT University, Australia, and the Department of Microbiology and Infectious Diseases, Royal Children's and Royal Women's Hospitals, Australia.