Impact of human immunodeficiency virus infection in pregnant women on variant-specific immunity to malaria
Edson G Dembo, Victor Mwapasa, Jacqui Montgomery, Alister G Craig, Kimberly A Porter, Steven R Meshnick, Malcolm E Molyneux, Stephen J Rogerson
CLINICAL AND VACCINE IMMUNOLOGY | AMER SOC MICROBIOLOGY | Published : 2008
Human immunodeficiency virus (HIV) increases susceptibility to Plasmodium falciparum infection, and this has most clearly been demonstrated in pregnant women. Variant surface antigens on the surfaces of erythrocytes infected with P. falciparum are major targets of protective immunity. We studied the impact of HIV infection on pregnant women's humoral immunity to variant surface antigens expressed by placental and pediatric isolates of P. falciparum. By flow cytometry, sera from HIV-infected women more frequently lacked antibodies to these antigens than sera from HIV-uninfected women. This difference was similar in magnitude for pediatric isolates (unadjusted odds ratio [OR] = 6.36; 95% confi..View full abstract
Awarded by Wellcome Trust
Awarded by NIAID
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
We thank Mavuto Mukaka for assistance with statistical analysis and acknowledge the fantastic efforts of Deborah Kamwendo, the study nurses, and the laboratory staff who recruited patients to the study. Labes Njiragoma, Annie Munthali, and Veronica Uzalili assisted with the collection of placental isolates; and Terrie Taylor coordinated collection of children's isolates.S.J.R., J.M., and M.E.M. were funded by the Wellcome Trust (senior fellowship 063215 to S.J.R., project grant 071376 to J.M., and programme grant 074124 to M.E.M.). This work was also supported by the National Health and Medical Research Council of Australia (project grant to S. J.R.) and by the NIAID (grant AI 49084 to S.R.M.).