Journal article

High-throughput genotyping of Salmonella enterica serovar typhi allowing geographical assignment of Haplotypes and pathotypes within an urban district of Jakarta, Indonesia

Stephen Baker, Kathryn Holt, Esther van de Vosse, Philippe Roumagnac, Sally Whitehead, Emma King, Philip Ewels, Andrew Keniry, Francois-Xavier Weill, Diane Lightfoot, Jaap T van Dissel, Kenneth E Sanderson, Jeremy Farrar, Mark Achtman, Panagiotis Deloukas, Gordon Dougan

JOURNAL OF CLINICAL MICROBIOLOGY | AMER SOC MICROBIOLOGY | Published : 2008

Abstract

High-throughput epidemiological typing systems that provide phylogenetic and genotypic information are beneficial for tracking bacterial pathogens in the field. The incidence of Salmonella enterica serovar Typhi infection in Indonesia is high and is associated with atypical phenotypic traits such as expression of the j and the z66 flagellum antigens. Utilizing a high-throughput genotyping platform to investigate known nucleotide polymorphisms dispersed around the genome, we determined the haplotypes of 140 serovar Typhi isolates associated with Indonesia. We identified nine distinct serovar Typhi haplotypes circulating in Indonesia for more than 30 years, with eight of these present in a sin..

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University of Melbourne Researchers