Journal article

Expression and localisation of the essential copper transporter DmATP7 in Drosophila neuronal and intestinal tissues

Richard Burke, Elizabeth Commons, James Camakaris

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2008

Abstract

Copper homeostasis is achieved by a combination of regulated uptake, efflux and sequestration and is essential for animal health and viability. Transmembrane copper transport proteins of the P-type ATPase family play key roles in cellular copper efflux. Here, the transcriptional and post-translational regulation of DmATP7, the sole Drosophila melanogaster ortholog of the human MNK and WND copper transport genes, is examined. An enhancer element with sufficient regulatory information to rescue DmATP7 mutant flies to adulthood is identified. This regulatory element drives expression in all neuronal tissues examined and demonstrates copper-inducible, Mtf-1 dependent expression in the larval mid..

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University of Melbourne Researchers