Journal article

The Utility of ADCC Responses in HIV Infection

Amy Chung, Erik Rollman, Susanne Johansson, Stephen J Kent, Ivan Stratov

CURRENT HIV RESEARCH | BENTHAM SCIENCE PUBL LTD | Published : 2008

Abstract

Simple antibodies or vector-induced T cell immunity are unable to provide broad immunity to HIV. Although broadly reactive neutralising antibodies are a goal of vaccination, this remains elusive. There is growing evidence that HIV-specific antibodies that mediate their activity via the Fc-receptor, such as antibody dependent cellular cytotoxicity (ADCC), have an important role in controlling HIV infection. Newer assays are being developed that enable HIV-specific ADCC responses to be finely mapped. In turn, this should allow a more definitive analysis of the effectiveness of HIV-specific ADCC antibodies. However, progressive dysfunction of effector cells that mediate ADCC responses, such as ..

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