Journal article

Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans

Wee Kian Yeo, Sarah J Lessard, Zhi-Ping Chen, Andrew P Garnham, Louise M Burke, Donato A Rivas, Bruce E Kemp, John A Hawley

JOURNAL OF APPLIED PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2008

Abstract

We have previously reported that 5 days of a high-fat diet followed by 1 day of high-carbohydrate intake (Fat-adapt) increased rates of fat oxidation and decreased rates of muscle glycogenolysis during submaximal cycling compared with consumption of an isoenergetic high-carbohydrate diet (HCHO) for 6 days (Burke et al. J Appl Physiol 89: 2413-2421, 2000; Stellingwerff et al. Am J Physiol Endocrinol Metab 290: E380-E388, 2006). To determine potential mechanisms underlying shifts in substrate selection, eight trained subjects performed Fat-adapt and HCHO. On day 7, subjects performed 1-h cycling at 70% peak O2 uptake. Muscle biopsies were taken immediately before and after exercise. Resting mu..

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University of Melbourne Researchers