Journal article

The acid-base effect of changing citrate solution for regional anticoagulation during continuous veno-venous hemofiltration

M Egi, T Naka, R Bellomo, C Langenberg, W Li, N Fealy, I Baldwin

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | WICHTIG EDITORE | Published : 2008

Abstract

PURPOSE: To compare the acid-base balance effects of two different citrate doses for regional citrate anticoagulant (RCA) for continuous veno-venous hemofiltration (CVVH). METHODS: We used a commercial citrate fluid (citrate concentration: 11 mmol/L) from July 2003 to July 2004 (period A) in 22 patients; then changed to a new citrate fluid (citrate concentration: 14 mmol/L) from July 2004 to Feb 2005 (Period B) in 21 patients. Replacement fluid rate was fixed at 2,000 ml/h. We measured all relevant variables for acid-base analysis according to the Stewart-Figge methodology. RESULTS: After commencement of RCA-CVVH, there was a change in bicarbonate and base excess (BE) toward acidosis for bot..

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University of Melbourne Researchers