Journal article

Continuous versus intermittent renal replacement therapy for critically ill patients with acute kidney injury: A meta-analysis

Sean M Bagshaw, Luc R Berthiaume, Anthony Delaney, Rinaldo Bellomo

CRITICAL CARE MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2008

Abstract

OBJECTIVE: To appraise the literature on the effect of initial renal replacement therapy (RRT) modality on clinical outcomes. DESIGN: Systematic review and meta-analysis. SETTING: Academic medical center. PATIENTS AND PARTICIPANTS: Adult critically ill patients with acute kidney injury. INTERVENTIONS: Continuous vs. intermittent RRT. MEASUREMENTS AND RESULTS: MEDLINE, EMBASE, Cochrane Controlled Clinical Trials Register, and other sources were searched. We identified nine unique randomized trials (n = 1,403). No trial satisfied all quality indicators and several had limitations related to selection bias, randomization, imbalances in patient characteristics, and high treatment crossover. No t..

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University of Melbourne Researchers