Journal article
Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition
SJ Borgwardt, P Allen, S Bhattacharyya, P Fusar-Poli, JA Crippa, ML Seal, V Fraccaro, Z Atakan, R Martin-Santos, C O'Carroll, K Rubia, PK McGuire
Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2008
Abstract
Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, ..
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Awarded by Psychiatry Research Trust
Funding Acknowledgements
This study tows supported by grants from the Psychiatry Research Trust, United Kingdom. SB is supported by an MRC Clinical Research Training Fellowship. TIP is supported by the Guy's & St. Thomas Charitable Foundation, New Services and Innovations in Health Care. All authors have agreed to the submission of this article in this form, and we do not have any conflict interests that might be interpreted as influencing its content. The authors reported no biomedical financial interest or potential conflicts of interest. Supplementary material cited in this article is available online.