Journal article
Impact of early dose intensity on cytogenetic and molecular responses in chronicphase CMLpatients receiving 600 mg/day of imatinib as initial therapy
TP Hughes, S Branford, DL White, J Reynolds, R Koelmeyer, JF Seymour, K Taylor, C Arthur, A Schwarer, J Morton, J Cooney, MF Leahy, P Rowlings, J Catalano, M Hertzberg, R Filshie, AK Mills, K Fay, S Durrant, H Januszewicz Show all
Blood | Published : 2008
Abstract
We conducted a trial in 103 patients with newly diagnosed chronic phase chronic myeloid leukemia (CP-CML) using imatinib 600 mg/day, with dose escalation to 800 mg/day for suboptimal response. The estimated cumulative incidences of complete cytogenetic response (CCR) by 12 and 24 months were 88% and 90%, and major molecular responses (MMRs) were 47% and 73%. In patients who maintained a daily average of 600 mg of imatinib for the first 6 months (n = 60), MMR rates by 12 and 24 months were 55% and 77% compared with 32% and 53% in patients averaging less than 600 mg (P = .037 and .016, respectively). Dose escalation was indicated for 17 patients before 12 months for failure to achieve, or main..
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Funding Acknowledgements
This work was supported in part by grants from Novartis Pharmaceuticals Australia and Amgen Australia. T. P. H. is a National Health and Medical Research Council Practitioner Fellow.