Bone marrow lesions predict progression of cartilage defects and loss of cartilage volume in healthy middle-aged adults without knee pain over 2 yrs
Anita Wluka, Y Wang, M Davies-Tuck, DR English, GG Giles, Flavia M Cicuttini
RHEUMATOLOGY | OXFORD UNIV PRESS | Published : 2008
OBJECTIVE: In knee OA, the presence of bone marrow lesions (BMLs) predicts pain and progression of disease. Their occurrence has been described in healthy, pain-free subjects, but whether their presence affects change in cartilage is unknown. METHODS: Two hundred and seventy-one healthy community-dwelling adults with no history of knee injury, knee pain or clinical knee OA had an MRI performed on their dominant knee at baseline and 2 yrs later to assess the relationship between the presence of BMLs at baseline and change in tibiofemoral cartilage defects and tibial cartilage volume over 2 yrs. RESULTS: BMLs were present in 37 (14%) subjects. Cartilage defects were more likely to progress rat..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by NHMRC
Funding: The Melbourne Collaborative Cohort Study recruitment was funded by VicHealth and The Cancer Council Victoria. This study was funded by a program grant from the National Health and Medical Research Council ( NHMRC; 209057) and was further supported by infrastructure provided by The Cancer Council Victoria. We would like to acknowledge the NHMRC ( project grant 334150) and Colonial Foundation. A. E. W. and Y. W. are the recipients of NHMRC Public Health Fellowships ( 317840 and 465142, respectively). M. D.-T. is the recipient of an Australian Postgraduate Award PhD Scholarship.