Journal article

Modeling proliferative tissue growth: A general approach and an avian case study

Benjamin J Binder, Kerry A Landman, Matthew J Simpson, Michael Mariani, Donald F Newgreen

PHYSICAL REVIEW E | AMER PHYSICAL SOC | Published : 2008

Abstract

During development, tissues often undergo rapid physical expansion due to cell proliferation. Continuous and discrete models of one- and two-dimensional tissue growth are developed and applied to observational data of the developing avian gut, where the gut tissue cells undergo dramatic proliferation. The discrete cellular automata model provides results at the level of individual cells that reflect a realistic stochasticity and nonuniformity expected in cellular systems. Averaging the discrete results predicts population-level properties of the system, which match those of the continuous model. This dual approach provides an understanding of the interaction between the individual-level and ..

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University of Melbourne Researchers