Colostrum supplementation restores insulin-like growth factor -1 levels and alters muscle morphology following massive small bowel resection

Abstract

Background: Colostrum protein concentrate (CPC) contains a high level of insulin-like growth factor-1 (IGF-1). IGF-1 and IGF binding protein (IGFBPs) may play an important role during the postresection adaptation response. As smooth muscle is an important site for IGF-1 action in the intestine, this study aims to (1) investigate the effect of CPC supplementation on circulating levels and tissue expression of IGF-1, IGF-1 receptor, and IGFBPs following massive small bowel resection (MSBR), and (2) characterize the effect of CPC on the muscular adaptation response following MSBR. Methods: Four-week-old piglets underwent either a 75% MSBR or sham operation. Piglets received either a polymeric i..