Journal article

24-hour colonic manometry in pediatric slow transit constipation shows significant reductions in antegrade propagation

Sebastian K King, Anthony G Catto-Smith, Michael P Stanton, Jonathan R Sutcliffe, Dianne Simpson, Ian Cook, Phil Dinning, John M Hutson, Bridget R Southwell

AMERICAN JOURNAL OF GASTROENTEROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2008

Abstract

BACKGROUND: The physiological basis of slow transit constipation (STC) in children remains poorly understood. We wished to examine pan-colonic motility in a group of children with severe chronic constipation refractory to conservative therapy. METHODS: We performed 24 h pan-colonic manometry in 18 children (13 boys, 11.6 +/- 0.9 yr, range 6.6-18.7 yr) with scintigraphically proven STC. A water-perfused, balloon tipped, 8-channel, silicone catheter with a 7.5 cm intersidehole distance was introduced through a previously formed appendicostomy. Comparison data were obtained from nasocolonic motility studies in 16 healthy young adult controls and per-appendicostomy motility studies in eight cons..

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