Journal article

Non-structural protein NSP2 induces heterotypic antibody responses during primary rotavirus infection and reinfection in children

Carl D Kirkwood, Karen Boniface, Simone Richardson, Zenobia F Taraporewala, John T Patton, Ruth F Bishop

JOURNAL OF MEDICAL VIROLOGY | WILEY-BLACKWELL | Published : 2008

Abstract

Rotaviruses are the single most important causes of severe acute diarrhoea in children worldwide. Despite success in developing vaccines, there is still a lack of knowledge about many components of the immune response, particularly those to non-structural proteins. This study established radioimmunoprecipitation (RIP) assays using labeled G1P[8], G2P[4], and G4P[6] human rotaviruses to examine the spectrum and duration of rotavirus antibodies in sera collected sequentially for 18-36 months from 27 children after hospitalization for primary rotavirus gastroenteritis. Five children experienced rotavirus re-infections. Primary responses detected to non-structural protein NSP2 declined to baseli..

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