Journal article

Multiple Dendritic Cell Populations Activate CD4( ) T Cells after Viral Stimulation

Adele M Mount, Christopher M Smith, Fiona Kupresanin, Kristina Stoermer, William R Heath, Gabrielle T Belz

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2008

Abstract

Dendritic cells (DC) are a heterogeneous cell population that bridge the innate and adaptive immune systems. CD8alpha DC play a prominent, and sometimes exclusive, role in driving amplification of CD8(+) T cells during a viral infection. Whether this reliance on a single subset of DC also applies for CD4(+) T cell activation is unknown. We used a direct ex vivo antigen presentation assay to probe the capacity of flow cytometrically purified DC populations to drive amplification of CD4(+) and CD8(+) T cells following infection with influenza virus by different routes. This study examined the contributions of non-CD8alpha DC populations in the amplification of CD8(+) and CD4(+) T cells in cuta..

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Grants

Funding Acknowledgements

This work was funded by the National Health and Medical Research Council of Australia, a University of Melbourne Research Scholarship (A.M.M. and C.M.S.) and an NHMRC CJ Martin Fellowship (C.M.S), a Wellcome Trust Senior Overseas Fellowship (G.T.B.), Viertel Fellowship (G.T.B.) and Howard Hughes Medical Institute International Fellowships (G.T.B. and W.R. H)