Journal article

Cell-mediated rejection results in allograft loss after liver cell transplantation

Katrina J Allen, Nicole A Mifsud, Robert Williamson, Patrick Bertolino, Winita Hardikar

LIVER TRANSPLANTATION | JOHN WILEY & SONS INC | Published : 2008

Abstract

Liver cell transplantation in humans has been impeded by invariable loss of the graft. It is unclear whether graft loss is due to an immune response against donor hepatocytes. Transplantation with ABO-matched liver cells was performed in a patient with Crigler-Najjar type 1. After successful engraftment, there was a gradual loss of graft function. Solid-phase enzyme immunoassay testing and cell-complement cytotoxicity assays detecting preformed antibodies directed toward class I and/or class II human leukocyte antigen (HLA) molecules were negative. In contrast, a striking host alloresponse to either the HLA-B39 or C7 antigen was found, suggesting that a vigorous response to a defined mismatc..

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