Journal article

Calcitonin gene-related peptide inhibits angiotensin II-mediated vasoconstriction in human radial arteries: Role of the Kir channel

Anthony Zulli, Bei Ye, Peter J Wookey, Brian F Buxton, David L Hare

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | MOSBY-ELSEVIER | Published : 2008

Abstract

OBJECTIVE: The radial artery is increasingly used for coronary artery bypass grafts, but its potential for spasm increases postoperative risk. Alpha-calcitonin gene-related peptide is a potent antihypertensive peptide. Thus, we set out to determine whether calcitonin gene-related peptide can impair angiotensin II-mediated vasoconstriction in human radial arteries and, if so, to determine its mechanism of action. METHODS: Radial arteries were placed in organ bath chambers and preincubated with 10(-9) to 10(-7) mol/L alpha-calcitonin gene-related peptide for 20 minutes before initiating an angiotensin II dose response curve (10(-10)-10(-6) mol/L). RESULTS: Calcitonin gene-related peptide, 10(-..

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