Superantigen genes in group A streptococcal isolates and their relationship with emm types
Robert Commons, Susan Rogers, Travis Gooding, Margie Danchin, Jonathan Carapetis, Roy Robins-Browne, Nigel Curtis
JOURNAL OF MEDICAL MICROBIOLOGY | MICROBIOLOGY SOC | Published : 2008
Superantigens are important virulence factors in the pathogenesis of invasive disease caused by group A streptococcus (GAS). There has been a recent re-emergence of this disease worldwide. A number of novel superantigens have been described recently. This study investigated 107 isolates of GAS for possession of each of the 11 currently known superantigen genes to determine the prevalence, co-occurrence and genetic restriction amongst different emm types of GAS. The results were compared with those in previously published studies. Superantigen genes were not randomly distributed amongst GAS isolates. Certain combinations of superantigen genes were more common and the majority of emm types sho..View full abstract
We gratefully acknowledge laboratory assistance provided by Gowri Selvaraj and Andrea Bigham. This work was funded by grants from the National Heart Foundation of Australia and the National Health and Medical Research Council, Australia.