Journal article
Sensitive, selective, and irreversible inhibition of cyclooxygenase-2 activity
CS Nagano, AI Bush
Chemmedchem | WILEY-V C H VERLAG GMBH | Published : 2008
Abstract
(Graph Presented) Copper bracelet. We analyzed prostaglandin E2 (PGE2) production by cyclooxygenase 2 (COX-2) after exposure to biometals. Cu2+ was the only metal ion that decreased PGE2 production. These effects may explain the anti-inflammatory benefits of Cu 2+ and the Cu2+-indomethacin complex reported previously. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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