Journal article

Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study.

Joel M Dulhunty, Jeffrey Lipman, Simon Finfer, undefined Sepsis Study Investigators for the ANZICS Clinical Trials Group

Intensive Care Med | Springer Science and Business Media LLC | Published : 2008


OBJECTIVE: To compare the time course of organ dysfunction/failure, mortality and cause of death in patients with severe sepsis (SS) and patients with severe non-infectious systemic inflammatory response syndrome (SNISIRS). DESIGN: Secondary analysis of a multi-centre inception cohort study. SETTING: Twenty-three multidisciplinary intensive care units (ICUs) in Australia and New Zealand. PATIENTS AND PARTICIPANTS: 3,543 ICU admissions > or = 48 h or <48 h if SIRS and organ dysfunction present. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: ICU prevalence of SS and SNISIRS was 20% (707/3,543) and 28% (980/3,543), respectively. ICU mortality was similar in patients with SNISIRS and with SS (25..

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University of Melbourne Researchers