Cytokine related therapies for autoimmune disease
Terry B Strom, Maria Koulmanda
CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2008
In short, manipulation of cytokine pathways shows promise as a mean to tilt the balance of immunity toward tolerance. Effective and regulatory T cells vary in their response to a variety of cytokines. In particular, the ability of certain cytokines, for example, IL-2, to provide vital survival signals to regulatory cells and to trigger death of effector T cells or impede IL-15 driven expansion of memory cells has spurred several trials. The ability of IFNgamma, IL-4, TNFalpha, and lymphotoxin to exert selective effects upon crucial lymphocyte subset populations in vivo may also enable translation into potent therapies.
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
The authors are supported by grants from the National Institutes of Health (NIH) and the Juvenile Diabetes Research Foundation (JDRF). The authors declare no competing financial interests.