Journal article

Cytokine related therapies for autoimmune disease

Terry B Strom, Maria Koulmanda

CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2008

Abstract

In short, manipulation of cytokine pathways shows promise as a mean to tilt the balance of immunity toward tolerance. Effective and regulatory T cells vary in their response to a variety of cytokines. In particular, the ability of certain cytokines, for example, IL-2, to provide vital survival signals to regulatory cells and to trigger death of effector T cells or impede IL-15 driven expansion of memory cells has spurred several trials. The ability of IFNgamma, IL-4, TNFalpha, and lymphotoxin to exert selective effects upon crucial lymphocyte subset populations in vivo may also enable translation into potent therapies.

University of Melbourne Researchers

Grants

Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

The authors are supported by grants from the National Institutes of Health (NIH) and the Juvenile Diabetes Research Foundation (JDRF). The authors declare no competing financial interests.